3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione

Base Information

• Chemical Name: 3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione
• CAS No.: 115288-71-6
• Molecular Formula: C₂₈H₃₆N₂O₃SSi
• Molecular Weight: 508.757
• Mol file: 115288-71-6.mol

Synonyms:3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione

Chemical Property of 3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione

There total 7 articles about 3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-Diacetyl-3-[1-{3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione → 3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione (115288-71-6)

Guidance literature:

With ammonia; In methanol; Yield given; Ambient temperature;

DOI:10.1021/ja00223a052

Reference yield:

chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2) → 3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione (115288-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: i-Pr₂NEt / 1,2-dichloro-ethane / 70 °C

2: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / -78 °C

3: NH₃ / methanol / Ambient temperature

With potassium tert-butylate; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; tert-butyl alcohol;

DOI:10.1021/ja00223a052

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → 3-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-((E)-3-phenylsulfanyl-allyl)-piperazine-2,5-dione (115288-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: i-Pr₂NEt / 1,2-dichloro-ethane / 70 °C

2: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / -78 °C

3: NH₃ / methanol / Ambient temperature

With potassium tert-butylate; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; tert-butyl alcohol;

DOI:10.1021/ja00223a052

upstream raw materials:

chlorodimethyl(1,1,2-trimethylpropyl)silane

thiophenol

meta-hydroxybenzaldehyde

3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzaldehyde

Downstream raw materials:

(1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester

(1R,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester

(2S,3S,5R)-3-Acetoxymethyl-2-[(R)-1-amino-2-(2-bromo-5-hydroxy-phenyl)-ethyl]-5-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester; compound with trifluoro-acetic acid

C₃₃H₃₆BrN₃O₈