(1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester
• CAS No.: 115288-85-2
• Molecular Formula: C₃₀H₃₇BrN₂O₈
• Molecular Weight: 633.536

Synonyms:

Chemical Property of (1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester

There total 37 articles about (1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl glyoxylate (7633-32-1) + (2S,3S,5R)-3-Acetoxymethyl-2-[(R)-1-amino-2-(2-bromo-5-hydroxy-phenyl)-ethyl]-5-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester; compound with trifluoro-acetic acid (115288-84-1) → (1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester (115288-85-2,115361-92-7)

Guidance literature:

In methanol; at 120 ℃; for 0.333333h; Yield given;

DOI:10.1021/ja00223a052

Reference yield:

tert-butyl glyoxylate (7633-32-1) + (2S,3S,5R)-3-Acetoxymethyl-2-[(R)-1-amino-2-(2-bromo-5-hydroxy-phenyl)-ethyl]-5-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester; compound with trifluoro-acetic acid (115288-84-1) → (1R,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester (115288-85-2,115361-92-7) + (1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester (115288-85-2,115361-92-7)

Guidance literature:

In methanol; at 120 ℃; for 0.333333h; Yield given. Yields of byproduct given;

DOI:10.1021/ja00223a052

Reference yield:

tert-butyl glyoxylate (7633-32-1) + (2S,3S,5R)-3-Acetoxymethyl-2-[(R)-1-amino-2-(2-bromo-5-hydroxy-phenyl)-ethyl]-5-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester; compound with trifluoro-acetic acid (115288-84-1) → (1R,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester (115288-85-2,115361-92-7) + (1S,3R)-3-((2S,3S,5R)-3-Acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-8-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester (115288-85-2,115361-92-7)

Guidance literature:

In methanol; at 120 ℃; for 0.333333h; Yield given. Yields of byproduct given;

DOI:10.1021/ja00223a052

upstream raw materials:

tert-butyl glyoxylate

(2S,3S,5R)-3-Acetoxymethyl-2-[(R)-1-amino-2-(2-bromo-5-hydroxy-phenyl)-ethyl]-5-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester; compound with trifluoro-acetic acid

meta-hydroxybenzaldehyde

3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzaldehyde

Downstream raw materials:

(1R,3R)-8-Acetoxy-3-((2S,3S,5R)-3-acetoxymethyl-1-benzyloxycarbonyl-5-hydroxymethyl-pyrrolidin-2-yl)-5-bromo-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid tert-butyl ester

C₃₃H₃₆BrN₃O₈

C₃₂H₃₆BrN₃O₇

C₃₁H₃₄BrN₃O₇

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