Technology Process of tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate
There total 11 articles about tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: 81 percent / Na2CO3 / H2O / 5 h / Ambient temperature
2: 91 percent / H2 / 5percent Pd-C / methanol / Ambient temperature
3: 68 percent / DEPC, Et3N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.
4: 74 percent / NaH / dimethylformamide / 0.33 h
5: 71 percent / N2H4*H2O / ethanol / 1 h / Heating
6: 18 percent / NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
With
4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate;
palladium on activated charcoal;
In
methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / H2 / 10 percent Pd-C / ethanol / Ambient temperature
2: 1) NaOEt; 2) H2SO4, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h
3: 18 percent / NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
With
4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; sodium chloride;
palladium on activated charcoal;
In
ethanol; acetic acid;
DOI:10.1248/cpb.34.1128
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 60 percent / NaNO2 / Ambient temperature
2: 81 percent / Na2CO3 / H2O / 5 h / Ambient temperature
3: 91 percent / H2 / 5percent Pd-C / methanol / Ambient temperature
4: 68 percent / DEPC, Et3N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.
5: 74 percent / NaH / dimethylformamide / 0.33 h
6: 71 percent / N2H4*H2O / ethanol / 1 h / Heating
7: 18 percent / NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
With
4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate; sodium nitrite;
palladium on activated charcoal;
In
methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128
