3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

Base Information

Chemical Name:3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride
CAS No.:95779-55-8
Molecular Formula:C₂₃H₃₂N₂O₅S*ClH
Molecular Weight:485.044
Hs Code.:

Synonyms:3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

Suppliers and Price of 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

There total 12 articles about 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 95779-49-0
tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate

: 95779-55-8
3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 60115-45-9
S-(o-nitrophenyl)-L-cysteine

: 95779-55-8
3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / Na₂CO₃ / H₂O / 5 h / Ambient temperature

2: 91 percent / H₂ / 5percent Pd-C / methanol / Ambient temperature

3: 68 percent / DEPC, Et₃N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.

4: 74 percent / NaH / dimethylformamide / 0.33 h

5: 71 percent / N₂H₄*H₂O / ethanol / 1 h / Heating

6: 18 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

7: 92 percent / 5 N HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; 4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 6048-09-5
3-cyclohexylacrylic acid ethyl ester

: 95779-55-8
3(R)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / H₂ / 10 percent Pd-C / ethanol / Ambient temperature

2: 1) NaOEt; 2) H₂SO₄, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

3: 18 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 92 percent / 5 N HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; sodium chloride; palladium on activated charcoal; In ethanol; acetic acid; ethyl acetate;
DOI:10.1248/cpb.34.1128