3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman

Base Information

• Chemical Name: 3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman
• CAS No.: 157251-01-9
• Molecular Formula: C₁₇H₁₈O₄
• Molecular Weight: 286.328
• Mol file: 157251-01-9.mol

Synonyms:3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman

Chemical Property of 3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman

There total 1 articles about 3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-ol (66947-61-3) + 4-methoxy-benzaldehyde (123-11-5) → 3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman (157251-01-9)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo00094a022

Reference yield: 77.0%

3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman (157251-01-9) → (+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin (82780-51-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1021/jo00094a022

Reference yield:

3-(4'-Methoxyphenyl)-1-hydroxy-8-methoxyisochroman (157251-01-9) → hydrangenol (480-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / PCC / CH₂Cl₂ / 12 h / Ambient temperature

2: 83 percent / BBr₃ / CH₂Cl₂ / 3 h / Ambient temperature

With boron tribromide; pyridinium chlorochromate; In dichloromethane;

DOI:10.1021/jo00094a022

upstream raw materials:

5-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-ol

4-methoxy-benzaldehyde

Downstream raw materials:

(+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin

hydrangenol