Technology Process of 2-(2,6-Difluoro-phenyl)-[1,3]dioxolane
There total 2 articles about 2-(2,6-Difluoro-phenyl)-[1,3]dioxolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid; orthoformic acid triethyl ester;
In
1,2-dichloro-ethane;
at 80 ℃;
for 2h;
DOI:10.1021/jm950639r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: LDA / tetrahydrofuran
2: PPTs
With
pyridinium p-toluenesulfonate; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.05.093
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) n-BuLi / 1.) THF, -70 deg C, 20 min, 2.) THF, from -70 deg C to RT
2: SOCl2, N,N-diisopropylamine / CH2Cl2 / 0 - 20 °C
3: CH2Cl2 / 0.5 h
4: p-TSA / H2O; dioxane / 2 h / 60 °C
5: toluene / 0.5 h / 50 °C
6: H2 / 10percent Pd/C / methanol; acetic acid / 1 h / 51.7 Torr
7: Et3N
With
n-butyllithium; thionyl chloride; hydrogen; toluene-4-sulfonic acid; triethylamine; diisopropylamine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1021/jm950639r
