1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine

Base Information

Chemical Name:1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine
CAS No.:75590-35-1
Molecular Formula:C₃₀H₃₁ClN₂O₄
Molecular Weight:519.04
Hs Code.:

Synonyms:1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine

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Chemical Property of 1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine

Chemical Property:

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Technology Process of 1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine

There total 3 articles about 1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39577-03-2
1-[(4-chlorophenyl)methyl]-4-(3-chloropropyl)piperazine

: 63360-23-6
4-(benzyloxy)-7-hydroxycoumarin

: 75590-35-1
1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 100 deg C, 1 h, 2.) DMF, 100 deg C, 4 h;
DOI:10.1021/jm00377a013

Reference yield:

: 23145-88-2
1-[(4-chlorophenyl)methyl]piperazine

: 75590-35-1
1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / K₂CO₃ / butan-2-one / 3 h / Heating

2: 1.) NaH / 1.) DMF, 100 deg C, 1 h, 2.) DMF, 100 deg C, 4 h

With sodium hydride; potassium carbonate; In butanone;
DOI:10.1021/jm00377a013

Reference yield:

: 55037-87-1
ethyl 4-(4-chlorobenzyl)piperazine-1-carboxylate

: 75590-35-1
1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 20percent w/v aq. NaOH / 2-ethoxy-ethanol / 18 h / Heating

2: 80 percent / K₂CO₃ / butan-2-one / 3 h / Heating

3: 1.) NaH / 1.) DMF, 100 deg C, 1 h, 2.) DMF, 100 deg C, 4 h

With sodium hydroxide; sodium hydride; potassium carbonate; In 2-ethoxy-ethanol; butanone;
DOI:10.1021/jm00377a013