39577-03-2

Upstream product

• 23145-88-2 1-[(4-chlorophenyl)methyl]piperazine 
• 109-70-6 1.3-chlorobromopropane 
• 78-93-3 butanone 
• 55037-87-1 ethyl 4-(4-chlorobenzyl)piperazine-1-carboxylate 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 87460-72-8 4-amino-1-<3-<4-(p-chlorobenzyl)piperazinyl>propyl>-5-cyanoimidazole 
• 87460-71-7 5-amino-1-<3-<4-(p-chlorobenzyl)piperazinyl>propyl>-4-cyanoimidazole 
• 108575-52-6 7-<3-<4-(p-chlorobenzyl)piperazinyl>propyl>-6-methylamino-2-methyldithiocarbamylpurine 
• 108575-53-7 7-<3-<4-(p-chlorobenzyl)piperazinyl>propyl>-6-methylamino-2-thioxopurine 
• 87469-94-1 1-(3-{3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-propyl}-5-cyano-3H-imidazol-4-yl)-3-methyl-urea 
• 87469-60-1 7-{3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-propyl}-6-imino-1-methyl-1,3,6,7-tetrahydro-purin-2-one 
• 87469-59-8 9-{3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-propyl}-6-imino-1-methyl-1,3,6,9-tetrahydro-purin-2-one 
• 87469-95-2 1-(1-{3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-propyl}-5-cyano-1H-imidazol-4-yl)-3-methyl-urea 
• 75590-38-4 7-{3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-propoxy}-4-hydroxy-3-nitro-chromen-2-one; compound with nitric acid 
• 75590-36-2 1-(4-chlorobenzyl)-4-[3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine 
• 75590-35-1 1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>propyl>-4-(4-chlorobenzyl)piperazine 
• 39577-20-3 3,4-dimethyl-7-<4-(4-chlorobenzyl)piperazin-1-yl>propoxycoumarin dihydrochloride 

Relevant academic research and scientific papers

Chemical synthesis of picumast dihydrochloride

The chemical synthesis of the antiallergic substance picumast dihydrochloride (3,4-dimethyl-7-[4-(4-chlorobenzyl)piperazine-1-yl]propoxycoumarin dihydrochloride) is described.

N-Benzylpiperazino Derivatives of 3-Nitro-4-hydroxycoumarin with H1 Antihistamine and Mast Cell Stabilizing Properties

In a small range finding study a number of N-benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin have been shown to combine potent H1-antihistamine activity with that of mast cell stabilization as demonstrated by their activity as antagonists of histamine on guinea pig ileum and by their inhibition of the release of histamine in rat passive peritoneal anaphylaxis (PPA).The most potent compound, 1-propyl>-4-(4-chlorobenzyl)piperazine, 30, had a pA2 of 9.0 against histamine on guinea pig ileum and inhibited histamine release in the rat PPA test with a potency similar to that of disodium cromoglycate.

Heterocyclic coumarin derivatives

A compound of formula (I): STR1 and pharmaceutically acceptable salts thereof, wherein R is hydrogen or an alkyl group containing up to 6 carbon atoms; X is a bond or oxygen; Y is --(CH2)n -- where n is 0 or an integer from 1 to 5 wh