ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate
CAS No.:1384513-07-8
Molecular Formula:C₂₂H₂₁ClINO₂
Molecular Weight:493.772
Hs Code.:

Synonyms:ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

There total 3 articles about ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1384513-05-6
ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 75-04-7,85404-22-4
ethylamine

: 1384513-07-8
ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: In methanol; Inert atmosphere;
DOI:10.1021/jm300608w

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1384513-07-8
ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; acetic acid / toluene / Inert atmosphere; Reflux

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere

3: methanol / Inert atmosphere

With piperidine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; In methanol; toluene; 3: Paal-Knorr pyrrole synthesis;
DOI:10.1021/jm300608w

Reference yield:

: ethyl 2-(3-iodobenzylidene)-3-oxobutanoate

: 1384513-07-8
ethyl 5-(4-chlorophenyl)-1-ethyl-4-(3-iodophenyl)-2-methyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere

2: methanol / Inert atmosphere

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; In methanol; 2: Paal-Knorr pyrrole synthesis;
DOI:10.1021/jm300608w