(2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

Base Information

Chemical Name:(2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one
CAS No.:139618-44-3
Molecular Formula:C₁₉H₂₂O₂
Molecular Weight:282.382
Hs Code.:

Synonyms:(2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

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Chemical Property of (2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

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Technology Process of (2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

There total 1 articles about (2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 635-26-7
o-tolylhydrazine hydrochloride

: 139685-68-0
(3aS,4R,7S,7aR)-2-Methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

: 139618-45-4
C₁₉H₂₂O₂

: 139618-44-3
(2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

Guidance literature:: With pyridine; sulfuric acid; sodium nitrite; Yield given. Multistep reaction. Yields of byproduct given; 1) water, reflux, 2) 0 deg C;
DOI:10.1016/S0040-4039(00)74123-2

Reference yield:

: 139618-44-3
(2S,3aS,4R,7S,7aR)-2-(2-Methoxy-4-methyl-phenyl)-2-methyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one

: 6790-63-2
(-)-Aplysin

Guidance literature:: Multi-step reaction with 8 steps

1: Li diisopropylamide / tetrahydrofuran

2: various solvent(s) / Heating

3: tetrahydrofuran

4: PCC / CH₂Cl₂

5: 60 percent / BBr₃ / 1,2-dichloro-ethane / 80 °C

6: 1) i-Bu₂AlH, 2) 10percent aq. HCl

7: 83 percent / H₂ / PtO₂ / ethanol

8: 87 percent / N-bromosuccinimide / CCl₄ / Heating

With hydrogenchloride; N-Bromosuccinimide; hydrogen; boron tribromide; diisobutylaluminium hydride; pyridinium chlorochromate; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)74123-2