Technology Process of ethyl 2-benzoyl-4-benzyloxy-5-methoxybenzoate
There total 4 articles about ethyl 2-benzoyl-4-benzyloxy-5-methoxybenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 4-benzyloxy-2-iodo-5-methoxybenzoate;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
benzoic acid anhydride;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 1h;
With
hydrogenchloride; water;
In
tetrahydrofuran; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium chlorite; sulfuric acid / acetonitrile; water; dimethyl sulfoxide / 0.5 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C
With
sodium chlorite; sulfuric acid; isopropylmagnesium chloride; potassium carbonate;
In
tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: iodine; silver trifluoroacetate / dichloromethane / 2 h / 20 °C
2.1: sodium chlorite; sulfuric acid / acetonitrile; water; dimethyl sulfoxide / 0.5 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 20 °C
With
sodium chlorite; sulfuric acid; iodine; isopropylmagnesium chloride; silver trifluoroacetate; potassium carbonate;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
