N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide

Base Information

Chemical Name:N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide
CAS No.:850147-93-2
Molecular Formula:C₂₆H₂₇ClN₆O₃S
Molecular Weight:539.058
Hs Code.:

Synonyms:N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide

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Chemical Property of N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide

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Technology Process of N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide

There total 5 articles about N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 850148-21-9
N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid sulfanyl-phenylcarboxamide

: 506-59-2
N,N-dimethylammonium chloride

: 850147-93-2
N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide

Guidance literature:: With 4-methyl-morpholine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile; at 60 ℃; for 2h;

Reference yield:

: 850148-18-4
(2-amino-5-acetic acid methyl ester sulfanyl-phenyl)-N-(5-chloro-(2-pyridyl))carboxamide

: 850147-93-2
N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.5 h / 20 °C

2.1: hydrogen sulfide; triethylamine / pyridine / 3.17 h / 20 °C

2.2: 1.5 h / Heating / reflux

3.1: acetic acid / tetrahydrofuran; methanol / 0.67 h / Heating / reflux

4.1: lithium hydroxide; water / methanol / 0.5 h / 20 °C

5.1: 4-methyl-morpholine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; acetonitrile / 2 h / 60 °C

With 4-methyl-morpholine; lithium hydroxide; hydrogen sulfide; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: N-(5-chloro(2-pyridyl)){5-acetic acid methyl ester sulfanyl-2-[(4-(iminomethylthiomethyl)phenyl)carbonylamino]phenyl}carboxamide

: 850147-93-2
N-(5-chloro-2-pyridinyl)-2-(4-N,N-dimethylamidinophenylcarbonyl)amino-5-acetic acid dimethylamide sulfanylphenylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / tetrahydrofuran; methanol / 0.67 h / Heating / reflux

2: lithium hydroxide; water / methanol / 0.5 h / 20 °C

3: 4-methyl-morpholine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; acetonitrile / 2 h / 60 °C

With 4-methyl-morpholine; lithium hydroxide; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;