(3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide

Base Information

• Chemical Name: (3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide
• CAS No.: 110638-63-6
• Molecular Formula: C₁₁H₁₄ClN₂OP
• Molecular Weight: 256.672

Synonyms:(3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide

Chemical Property of (3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide

Chemical Property:

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Technology Process of (3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide

There total 1 articles about (3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S)-2-(anilinomethyl)pyrrolidine (64030-44-0) → (3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide (110638-63-6) + (3R,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide (110715-46-3)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; at -78 ℃; for 2h; Yield given;

DOI:10.1039/c39950000435

Reference yield: 88.0%

piperazine (110-85-0) + (3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide (110638-63-6) → 1,4-bis[(5S)-1,3-diaza-2-phospha-2-oxo-3-phenylbicyclo(3.3.0)octan-2-yl]piperazine

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/S0957-4166(01)00101-X

Reference yield: 82.9%

(3S,7aS)-3-chloro-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide (110638-63-6) + N,N-dimethylethylenediamine (108-00-9) → (3S,7aS)-3-<(2-(dimethylamino)ethyl)amino>-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide (110638-54-5)

Guidance literature:

In tetrahydrofuran; for 2.5h; Heating;

DOI:10.1021/jo00233a004

upstream raw materials:

(2S)-2-(anilinomethyl)pyrrolidine

Downstream raw materials:

(3S,7aS)-3-(4-imino-1,4-dihydropyridyl)-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide hydrochloride

(3S,7aS)-3-<(2-(dimethylamino)ethyl)amino>-1,2,5,6,7,7a-hexahydro-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide

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