2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride

Base Information

Chemical Name:2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride
CAS No.:1345609-64-4
Molecular Formula:C₂₁H₂₃ClFNO₂*ClH
Molecular Weight:412.331
Hs Code.:

Synonyms:2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride

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Chemical Property of 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride

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Technology Process of 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride

There total 6 articles about 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1345610-15-2
methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

: 1345609-64-4
2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride

Guidance literature:: methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride; With water; sodium hydroxide; In methanol; for 14h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; for 1h;

Reference yield:

: 235109-63-4
4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

: 1345609-64-4
2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 14 h / 20 °C / Cooling with ice/salt bath

2.1: hydrogenchloride / methanol / 64 h / 20 °C

3.1: sodium hydrogencarbonate / methanol / 14 h / 20 °C

4.1: lithium hexamethyldisilazane / toluene / 1 h / Cooling with acetone-dry ice; Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: sodium hydroxide; water / methanol / 14 h / Reflux; Inert atmosphere

5.2: 1 h

With hydrogenchloride; diethylamino-sulfur trifluoride; water; sodium hydrogencarbonate; sodium hydroxide; lithium hexamethyldisilazane; In methanol; dichloromethane; toluene;

Reference yield:

: 1345610-13-0
methyl 3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate

: 1345609-64-4
2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / toluene / 1 h / Cooling with acetone-dry ice; Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 14 h / Reflux; Inert atmosphere

2.2: 1 h

With water; sodium hydroxide; lithium hexamethyldisilazane; In methanol; toluene;