methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

Base Information

Chemical Name:methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride
CAS No.:1345610-15-2
Molecular Formula:C₂₂H₂₅ClFNO₂*ClH
Molecular Weight:426.358
Hs Code.:

Synonyms:methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

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Chemical Property of methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

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Technology Process of methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

There total 5 articles about methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1345610-13-0
methyl 3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate

: 100-39-0
benzyl bromide

: 1345610-15-2
methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

Guidance literature:: methyl 3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate; With lithium hexamethyldisilazane; In toluene; for 1h; Cooling with acetone-dry ice; Inert atmosphere;

benzyl bromide; In toluene; at 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; ammonium chloride;

Reference yield:

: 235109-63-4
4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

: 1345610-15-2
methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 14 h / 20 °C / Cooling with ice/salt bath

2.1: hydrogenchloride / methanol / 64 h / 20 °C

3.1: sodium hydrogencarbonate / methanol / 14 h / 20 °C

4.1: lithium hexamethyldisilazane / toluene / 1 h / Cooling with acetone-dry ice; Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; diethylamino-sulfur trifluoride; sodium hydrogencarbonate; lithium hexamethyldisilazane; In methanol; dichloromethane; toluene;

Reference yield:

: 4-fluoro-4-(4-chlorophenyl)-1-piperidine hydrochloride

: 1345610-15-2
methyl 2-benzyl-3-[4-(4-chlorophenyl)-4-fluoropiperidin-1-yl]propionate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / methanol / 14 h / 20 °C

2.1: lithium hexamethyldisilazane / toluene / 1 h / Cooling with acetone-dry ice; Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; lithium hexamethyldisilazane; In methanol; toluene;