3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide

Base Information

• Chemical Name: 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide
• CAS No.: 1334740-34-9
• Molecular Formula: C₃₆H₃₈N₂O₇
• Molecular Weight: 610.707
• Mol file: 1334740-34-9.mol

Synonyms:3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide

Chemical Property of 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide

There total 5 articles about 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine (1221157-03-4) → 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide (1334740-34-9)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

4-hydroxy-3-nitrobenzaldehyde (3011-34-5) → 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide (1334740-34-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 40 °C

1.2: 70 °C

2.1: tetrahydrofuran; hexane / Cooling with ice; Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; 2.2: |Wittig Olefination;

DOI:10.1016/j.cclet.2015.05.003

Reference yield:

4-ethoxy-3-nitrobenzaldehyde (132390-61-5) → 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide (1334740-34-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran; hexane / Cooling with ice; Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; 1.2: |Wittig Olefination;

DOI:10.1016/j.cclet.2015.05.003

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine

4-ethoxy-3-nitrobenzaldehyde

4-hydroxy-3-nitrobenzaldehyde

Downstream raw materials:

2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide

Refernces

• 1、 -. "ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF". Page/Page column 12. . Retrieved 2011/08/08.