2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide

Base Information

• Chemical Name: 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide
• CAS No.: 1221157-04-5
• Molecular Formula: C₂₁H₂₈N₂O₅
• Molecular Weight: 388.464
• Mol file: 1221157-04-5.mol

Synonyms:2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide

Chemical Property of 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide

There total 6 articles about 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide (1334740-34-9) → 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide (1221157-04-5)

Guidance literature:

With methanol; sodium hydroxide; for 3h;

Reference yield:

4-hydroxy-3-nitrobenzaldehyde (3011-34-5) → 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide (1221157-04-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 40 °C

1.2: 70 °C

2.1: tetrahydrofuran; hexane / Cooling with ice; Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

5.1: sodium hydroxide; water / methanol / 3 h / 20 °C

With palladium 10% on activated carbon; water; hydrogen; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; 2.2: |Wittig Olefination;

DOI:10.1016/j.cclet.2015.05.003

Reference yield:

4-ethoxy-3-nitrobenzaldehyde (132390-61-5) → 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide (1221157-04-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran; hexane / Cooling with ice; Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

4.1: sodium hydroxide; water / methanol / 3 h / 20 °C

With palladium 10% on activated carbon; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; hexane; ethyl acetate; N,N-dimethyl-formamide; 1.2: |Wittig Olefination;

DOI:10.1016/j.cclet.2015.05.003

upstream raw materials:

4-ethoxy-3-nitrobenzaldehyde

4-hydroxy-3-nitrobenzaldehyde

3,4,5-trimethoxy-3'-nitro-4'-ethoxystilbene

2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine

Refernces

• 1、 -. "ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF". . . Retrieved 2011/08/08.