(R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine

Base Information

• Chemical Name: (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine
• CAS No.: 878757-08-5
• Molecular Formula: C₁₉H₂₁NOS
• Molecular Weight: 311.448
• Mol file: 878757-08-5.mol

Synonyms:(R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine

Chemical Property of (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine

There total 3 articles about (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-3-(1-naphthalenyloxy)-3-(thien-2-yl)propanamine oxalate (116817-12-0) → (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine (878757-08-5) + N-methyl-(S)-duloxetine (132335-46-7)

Guidance literature:

(+/-)-N,N-dimethyl-3-(l-naphthaleneoxy)-3-(2-thienyI)propanamine oxalate salt; With sodium hydroxide; In water;

With tartaric acid; Resolution of racemate;

Alkaline aqueous solution;

Reference yield:

1-Fluoronaphthalene (321-38-0) + (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol (132335-44-5) → (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine (878757-08-5) + N-methyl-(S)-duloxetine (132335-46-7)

Guidance literature:

With potassium tert-butylate; tetrabutylammomium bromide; In dimethyl sulfoxide; at 90 ℃; optical yield given as %ee;

DOI:10.1021/op800289h

Reference yield:

N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine (116817-11-9) → (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine (878757-08-5) + N-methyl-(S)-duloxetine (132335-46-7)

Guidance literature:

N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine; Resolution of racemate;

With water; Purification / work up; Basic aqueous solution;

upstream raw materials:

N,N-dimethyl-3-(1-naphthalenyloxy)-3-(thien-2-yl)propanamine oxalate

N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine

1-Fluoronaphthalene

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Downstream raw materials:

(R)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate

(S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate

(R)-(-)-N-methyl-3-(1-napthalenyloxy)-3-(2-thienyl)propanamine hydrochloride

N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine