(R)-duloxetine

Base Information Edit

Chemical Name:(R)-duloxetine
CAS No.:116539-60-7
Molecular Formula:C18H19ONS
Molecular Weight:297.421
Hs Code.:
UNII:TK9VOT90JQ
DSSTox Substance ID:DTXSID40151424
Nikkaji Number:J617.659C
Wikidata:Q27116966
Pharos Ligand ID:1UF5MMQBPHXL
Metabolomics Workbench ID:55487
ChEMBL ID:CHEMBL336920
Mol file:116539-60-7.mol

Synonyms:(R)-duloxetine;116539-60-7;Duloxetine, (R)-;(-)-Duloxetine;Duloxetine, (-)-;Duloxetine impurity A;UNII-TK9VOT90JQ;TK9VOT90JQ;(3R)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine;CHEMBL336920;CHEBI:36797;(r)-n-methyl-3-(1-naphthoxy)-3-(2-thienyl)propylamine;Duloxetine hydrochloride impurity A [EP];(3R)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine;(3R)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine;(3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine;Duloxetine hydrochloride specified impurity A [EP];2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (R)-;2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaR)-;R-Duloxetine HCl;D05UMA;SCHEMBL1200511;DTXSID40151424;AMY13847;BDBM50136674;PDSP1_000970;PDSP2_000954;AKOS015895877;AC-4731;AS-12985;LY248685;(3R)-LY-248686;Q27116966;DULOXETINE HYDROCHLORIDE IMPURITY A [EP IMPURITY];2-THIOPHENEPROPANAMINE, N-METHYL-.GAMMA.-(1-NAPHTHALENYLOXY)-, (.GAMMA.R)-;2-THIOPHENEPROPANAMINE, N-METHYL-.GAMMA.-(1-NAPHTHALENYLOXY)-, (R)-

Suppliers and Price of (R)-duloxetine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(3R)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine 95%+
100g
$ 1564.00

American Custom Chemicals Corporation
(R)-DULOXETINE 95.00%
5G
$ 909.56

AK Scientific
R-DuloxetineHCl
10mg
$ 69.00

Total 74 raw suppliers

Chemical Property of (R)-duloxetine Edit

Chemical Property:

Vapor Pressure:7.23E-09mmHg at 25°C
Refractive Index:1.627
Boiling Point:466.2 °C at 760 mmHg
PKA:10.02±0.10(Predicted)
Flash Point:235.7 °C
PSA：49.50000
Density:1.158 g/cm³
LogP:5.82380
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:297.11873540
Heavy Atom Count:21
Complexity:312

Purity/Quality:

99% ^*data from raw suppliers

(3R)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
Isomeric SMILES:CNCC[C@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32

Technology Process of (R)-duloxetine

There total 100 articles about (R)-duloxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

: 896446-94-9
duloxetine ethyl carbamate

: 116539-58-3,116539-59-4,116539-60-7,116817-13-1
Duloxetine

Guidance literature:: With potassium hydroxide; In ethanol; toluene; at 85 - 100 ℃; for 2h; Temperature;

Reference yield: 94.7%

: (S)-3-(1-naphthyloxy)-3-(2-thienyl)propionaldehyde

: 74-89-5
methylamine

: 116539-58-3,116539-59-4,116539-60-7,116817-13-1
Duloxetine

Guidance literature:: (S)-3-(1-naphthyloxy)-3-(2-thienyl)propionaldehyde; methylamine; In ethanol; at 60 - 65 ℃; for 4h;

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 - 30 ℃; for 4h; under 1500.15 - 3000.3 Torr; Reagent/catalyst; Temperature; Autoclave;