116817-12-0

Basic information

• Product Name: S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE
• Synonyms: (S)-N,N-DIMETHYL-3-(NAPHTHALEN-1-YLOXY)-3-(THIOPHEN-2-YL)PROPAN-1-AMINE;S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE;N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate
• CAS NO: 116817-12-0
• Molecular Formula: C19H21NOS·C2H2O4
• Molecular Weight: 401.48
• Mol File: 116817-12-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 459.744°C at 760 mmHg
• Flash Point: 231.845°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE(116817-12-0)
• EPA Substance Registry System: S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE(116817-12-0)

Safety Data

• Hazardous Substances Data: 116817-12-0(Hazardous Substances Data)

Usage

General Description

S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE, also known as Napamine, is a chiral compound that consists of a naphthyl group and a thienyl group connected to a propanamine backbone. It is used as a pharmaceutical intermediate in the synthesis of various drugs. Napamine has been studied for its potential use in the treatment of psychiatric and neurological disorders, as well as its potential anti-inflammatory and anti-cancer properties. It is important to handle this chemical with care, as it is known to be toxic if ingested or inhaled, and it can cause irritation to the eyes, skin, and respiratory system.

InChI:InChI=1/C19H21NOS/c1-20(2)13-12-18(19-11-6-14-22-19)21-17-10-5-8-15-7-3-4-9-16(15)17/h3-11,14,18H,12-13H2,1-2H3/t18-/m0/s1

Upstream product

• 321-38-0 1-Fluoronaphthalene 
• 132335-44-5 (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol 
• 144-62-7 oxalic acid 
• 116817-11-9 N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine 
• 132335-46-7 N-methyl-(S)-duloxetine 
• 878757-08-5 (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine 
• 13636-02-7 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol 
• 132335-49-0 α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol 
• 5424-47-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride 
• 88-15-3 2-Acetylthiophene 

Downstream Products

• 132335-46-7 N-methyl-(S)-duloxetine 
• 947686-09-1 (S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine 
• 878757-08-5 (R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine 
• 116817-11-9 N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine 

Relevant articles and documents

MANUFACTURING METHOD OF DULOXETINE HYDROCHLORIDE AND DULOXETINE HYDROCHLORIDE WITH NOVEL CRYSTAL STRUCTURE

PROBLEM TO BE SOLVED: To provide a method of providing crystal of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (general name:duloxetine hydrochloride) useful as an antidepressant with high purity and high bulk density. SOLUTION: There is provided a manufacturing method of duloxetine hydrochloride for depositing the duloxetine hydrochloride in a resulting mixture by mixing a solution by dissolving duloxetine hydrochloride into a solvent for dissolution containing at least one kind of polar solvent selected from water and alcohol having 1 to 3 carbon atoms with acetone, and setting a temperature when dissolving the duloxetine hydrochloride into the solvent for dissolution at 60°C or less. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT

AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE AND SALTS THEREOF

The present invention relates to improved process for the preparation of Duloxetine of formula (I) and salts thereof wherein said improvement takes place in step of condensation.

SYNTHESIS AND PREPARATIONS OF DULOXETINE SALTS

The invention relates to an improved process for the preparation of duloxetine hydrochloride.