2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

Base Information

Chemical Name:2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid
CAS No.:956368-72-2
Molecular Formula:C₁₆H₂₅FO₃SSi
Molecular Weight:344.523
Hs Code.:

Synonyms:2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

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Chemical Property of 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

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Technology Process of 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

There total 5 articles about 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1056209-19-8
methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

: 956368-72-2
2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

Guidance literature:: methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1056209-16-5
(1R)-2-bromo-1-(t-butyldimethylsilyloxy)-1-(4-fluorophenyl)ethane

: sodium mercaptoacetate

: 956368-72-2
2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene;

Reference yield:

: 1369489-38-2
methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 956368-72-2
2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

Guidance literature:: methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate; tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 18 - 27 ℃; Inert atmosphere;

With methanol; sodium hydroxide; at 10 - 17 ℃; for 16h; Inert atmosphere;
DOI:10.1021/op200314z