methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

Base Information

Chemical Name:methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate
CAS No.:1369489-38-2
Molecular Formula:C₁₁H₁₃FO₃S
Molecular Weight:244.287
Hs Code.:

Synonyms:

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Chemical Property of methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

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Technology Process of methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

There total 2 articles about methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1097211-38-5
(1R)-2-bromo-1-(4-fluorophenyl)ethan-1-ol

: methyl thioglycolate

: 1369489-38-2
methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

Guidance literature:: (1R)-2-bromo-1-(4-fluorophenyl)ethan-1-ol; methyl thioglycolate; With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 15h; Inert atmosphere;

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/op200314z

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1369489-38-2
methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 0.25 h / 4 - 7 °C / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 15 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

With dimethylsulfide borane complex; triethylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op200314z

Reference yield:

: 1369489-38-2
methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 956368-72-2
2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

Guidance literature:: methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate; tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 18 - 27 ℃; Inert atmosphere;

With methanol; sodium hydroxide; at 10 - 17 ℃; for 16h; Inert atmosphere;
DOI:10.1021/op200314z