methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

Base Information

Chemical Name:methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate
CAS No.:1056209-19-8
Molecular Formula:C₁₇H₂₇FO₃SSi
Molecular Weight:358.549
Hs Code.:

Synonyms:methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

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Technology Process of methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

There total 2 articles about methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1056209-16-5
(1R)-2-bromo-1-(t-butyldimethylsilyloxy)-1-(4-fluorophenyl)ethane

: 2365-48-2
Methyl thioglycolate

: 1056209-19-8
methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 40 ℃;

Reference yield:

: 1369489-38-2
methyl 2-[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thioacetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 18173-64-3
tert-butyldimethylsilanol

: 1056209-19-8
methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 18 - 27 ℃; Inert atmosphere;
DOI:10.1021/op200314z

Reference yield: 100.0%

: 1056209-19-8
methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate

: 956368-72-2
2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetic acid

Guidance literature:: methyl 2-[(2R)-2-[tert-butyl(dimethyl)silyl]oxy-2-(4-fluorophenyl)ethyl]thioacetate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;