2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

Base Information

Chemical Name:2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione
CAS No.:1391978-76-9
Molecular Formula:C₂₀H₂₁N₅O₄
Molecular Weight:395.418
Hs Code.:

Synonyms:2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

Chemical Property:

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Technology Process of 2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

There total 8 articles about 2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 67-56-1
methanol

: 1391978-74-7
2'-((2-azidoethyl)(benzyl)amino)-1'H-spiro[[1,3]dithiane-2,4'-isoquinoline]-1',3'(2'H)-dione

: 1391978-76-9
2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

Guidance literature:: With trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; at 23 ℃; for 0.25h; Inert atmosphere;
DOI:10.1039/c2ob25353d

Reference yield:

: 1391978-66-7
(E)-ethyl 2-(2-(2-azidoethyl)-2-benzylhydrazono)propanoate

: 1391978-76-9
2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine dihydrochloride; water / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

3: 2-Picolinic acid; copper(l) iodide; caesium carbonate / 1,4-dioxane / 3 h / 70 °C / Inert atmosphere

4: toluene-4-sulfonic acid / water; toluene / 20 h / Inert atmosphere; Reflux

5: triethylamine / dichloromethane / 21 h / 25 °C / Inert atmosphere

6: trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene / 0.25 h / 23 °C / Inert atmosphere

With 2-Picolinic acid; copper(l) iodide; hydrazine dihydrochloride; water; caesium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1039/c2ob25353d

Reference yield:

: 1391978-68-9
1-(2-azidoethyl)-1-benzylhydrazine

: 1391978-76-9
2-((2-azidoethyl)(benzyl)amino)-4,4-dimethoxyisoquinoline-1,3(2H,4H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

2: 2-Picolinic acid; copper(l) iodide; caesium carbonate / 1,4-dioxane / 3 h / 70 °C / Inert atmosphere

3: toluene-4-sulfonic acid / water; toluene / 20 h / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 21 h / 25 °C / Inert atmosphere

5: trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene / 0.25 h / 23 °C / Inert atmosphere

With 2-Picolinic acid; copper(l) iodide; caesium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1039/c2ob25353d