αS-(αR^*,βS^*,γS^*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester

Base Information

• Chemical Name: αS-(αR^*,βS^*,γS^*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester
• CAS No.: 110658-44-1
• Molecular Formula: C₂₃H₂₆N₆O₇
• Molecular Weight: 498.495
• Mol file: 110658-44-1.mol

Synonyms:αS-(αR^*,βS^*,γS^*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester

Chemical Property of αS-(αR^*,βS^*,γS^*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of αS-(αR^*,βS^*,γS^*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester

There total 2 articles about αS-(αR^*,βS^*,γS^*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

-4-<1-Benzyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purin-7-yl>-2-<(methoxycarbonyl)amino>-3-butenoic Acid Methyl Ester (96854-31-8) → <αS-(αR*,βR*,γR*)>-1-benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazol<1,2-a>purine-7-butanoic acid methyl ester (110582-30-4) + αS-(αR*,βS*,γS*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester (110658-44-1)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide;

DOI:10.1016/S0040-4039(00)84906-0

Reference yield:

1-benzyl-7-formylwye (96881-37-7) → αS-(αR*,βS*,γS*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester (110658-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, 4.) AcOH

2: 37 percent / OsO₄, 0.5 M phosphate buffer, N-methylmorpholine N-oxide / acetone; 2-methyl-propan-2-ol / 3 h / Ambient temperature

With osmium(VIII) oxide; n-butyllithium; phosphate buffer; acetic acid; 4-methylmorpholine N-oxide; In acetone; tert-butyl alcohol;

DOI:10.1248/cpb.46.1220

Reference yield: 55.0%

oxalyl dichloride (79-37-8) + αS-(αR*,βS*,γS*)-1benzyl-4,9-dihydro-β,γ-dihydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester (110658-44-1) → <4R-<4α(S*),5β>>-5-<1-benzyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purin-7-yl>-α-<(methoxycarbonyl)amino>-2-oxo-1,3-dioxolane-4-acetic acid methyl ester (110658-45-2)

Guidance literature:

With pyridine; In dichloromethane; toluene; at 0 ℃; for 0.166667h;

DOI:10.1248/cpb.46.1220

upstream raw materials:

-4-<1-Benzyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purin-7-yl>-2-<(methoxycarbonyl)amino>-3-butenoic Acid Methyl Ester

1-benzyl-7-formylwye

Downstream raw materials:

<4R-<4α(S^*),5β>>-5-<1-benzyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purin-7-yl>-α-<(methoxycarbonyl)amino>-2-oxo-1,3-dioxolane-4-acetic acid methyl ester

wybutine

*,R^*)>-4,9-dihydro-β-hydroxy-α-<(methoxycarbonyl)amino>-4,6-dimethyl-9-oxo-1H-imidazo<1,2-a>purine-7-butanoic acid methyl ester