2-(2-Hydroxyethyl)-N-[2-[3-(phenylmethoxy)phenoxy]ethyl]benzamide

Base Information

Chemical Name:2-(2-Hydroxyethyl)-N-[2-[3-(phenylmethoxy)phenoxy]ethyl]benzamide
CAS No.:748798-77-8
Molecular Formula:C₂₄H₂₅NO₄
Molecular Weight:391.467
Hs Code.:
DSSTox Substance ID:DTXSID601168192

Synonyms:DTXSID601168192;2-(2-Hydroxyethyl)-N-[2-[3-(phenylmethoxy)phenoxy]ethyl]benzamide;748798-77-8

Suppliers and Price of 2-(2-Hydroxyethyl)-N-[2-[3-(phenylmethoxy)phenoxy]ethyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Hydroxyethyl)-N-[2-[3-(phenylmethoxy)phenoxy]ethyl]benzamide

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:391.17835828
Heavy Atom Count:29
Complexity:466

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=CC=CC(=C2)OCCNC(=O)C3=CC=CC=C3CCO

Technology Process of 2-(2-Hydroxyethyl)-N-[2-[3-(phenylmethoxy)phenoxy]ethyl]benzamide

There total 5 articles about 2-(2-Hydroxyethyl)-N-[2-[3-(phenylmethoxy)phenoxy]ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 4702-34-5
isochroman-1-one

: 85300-32-9
2-[3-(benzyloxy)phenoxy]ethylamine

: 748798-77-8
2-(2-hydroxyethyl)-N-[2-(3-benzyloxyphenoxy)ethyl]benzamide

Guidance literature:: With ammonium chloride; at 120 ℃; for 8h;
DOI:10.1021/jm049720x

Reference yield:

: 3769-41-3
3-Benzyloxyphenol

: 748798-77-8
2-(2-hydroxyethyl)-N-[2-(3-benzyloxyphenoxy)ethyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / 16 h / 180 °C

2: 96 percent / aq. NaOH / ethanol / 36 h / Heating

3: 32 percent / NH₄Cl / 8 h / 120 °C

With sodium hydroxide; ammonium chloride; In ethanol;
DOI:10.1021/jm049720x

Reference yield:

: 100-39-0
benzyl bromide

: 748798-77-8
2-(2-hydroxyethyl)-N-[2-(3-benzyloxyphenoxy)ethyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / acetone / 1 h / Heating

1.2: 70 percent / acetone; acetonitrile / 96 h / Heating

2.1: 67 percent / 16 h / 180 °C

3.1: 96 percent / aq. NaOH / ethanol / 36 h / Heating

4.1: 32 percent / NH₄Cl / 8 h / 120 °C

With sodium hydroxide; potassium carbonate; ammonium chloride; In ethanol; acetone;
DOI:10.1021/jm049720x