(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

Base Information

Chemical Name:(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone
CAS No.:398133-32-9
Molecular Formula:C₂₁H₂₅FO₂SSi
Molecular Weight:388.578
Hs Code.:

Synonyms:(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

Suppliers and Price of (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

Chemical Property:

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Technology Process of (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

There total 11 articles about (2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 212954-52-4
(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-fluoro-5H-furan-2-one

: 398133-32-9
(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/C

2.1: NaOH

3.1: I₂; PPh₃; imidazole

4.1: dimethylformamide

5.1: DIBAL-H

5.2: acetic anhydride / dimethylsulfoxide

With 1H-imidazole; sodium hydroxide; hydrogen; iodine; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-120021965

Reference yield:

: 398133-29-4
(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone

: 398133-32-9
(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOH

2.1: I₂; PPh₃; imidazole

3.1: dimethylformamide

4.1: DIBAL-H

4.2: acetic anhydride / dimethylsulfoxide

With 1H-imidazole; sodium hydroxide; iodine; diisobutylaluminium hydride; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-120021965

Reference yield:

: 5-(tert-butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

: 398133-32-9
(2R,4R)-(-)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-thiobutyrolactone

Guidance literature:: Multi-step reaction with 3 steps

1.1: I₂; PPh₃; imidazole

2.1: dimethylformamide

3.1: DIBAL-H

3.2: acetic anhydride / dimethylsulfoxide

With 1H-imidazole; iodine; diisobutylaluminium hydride; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-120021965