2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide
CAS No.:1378428-82-0
Molecular Formula:C₂₀H₂₁FN₂O₄S
Molecular Weight:404.462
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

There total 3 articles about 2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1378428-80-8
2-(4-fluorophenyl)-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

: 74-89-5
methylamine

: 1378428-82-0
2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; for 15h; Inert atmosphere;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1378428-82-0
2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 25 h / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4: potassium hydroxide; water / ethanol / 0.5 h / Reflux

5: triethylamine; HATU / N,N-dimethyl-formamide / 15 h / Inert atmosphere

With potassium fluoride; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium bromide; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: ethyl 2-(4-fluorophenyl)-5-(1-methylethenyl)-6-nitro-1-benzofuran-3-carboxylate

: 1378428-82-0
2-(4-fluorophenyl)-N-methyl-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: potassium hydroxide; water / ethanol / 0.5 h / Reflux

4: triethylamine; HATU / N,N-dimethyl-formamide / 15 h / Inert atmosphere

With water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;