2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine

Base Information

Chemical Name:2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine
CAS No.:548740-17-6
Molecular Formula:C₃₄H₂₇F₆NO₆S
Molecular Weight:691.648
Hs Code.:

Synonyms:2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine

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Chemical Property of 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine

Chemical Property:

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Technology Process of 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine

There total 3 articles about 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35661-40-6
N-Fmoc L-Phe

: 450409-87-7
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]-1-ethanol

: 548740-17-6
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1055/s-2003-36844

Reference yield:

: 130783-02-7
3,5-bis(trifluoromethyl)thiophenol

: 548740-17-6
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Et₃N / acetonitrile / 24 h / 20 °C

2: MnSO₄; aq. H₂O₂; NaHCO₃ / acetonitrile / 20 °C

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1055/s-2003-36844

Reference yield:

: 450409-97-9
2-[3,5-di(trifluoromethyl)phenylsulfanyl]-1-ethanol

: 548740-17-6
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: MnSO₄; aq. H₂O₂; NaHCO₃ / acetonitrile / 20 °C

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1055/s-2003-36844