(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

Base Information

Chemical Name:(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol
CAS No.:120034-53-9
Molecular Formula:C₂₇H₃₀N₂O₄
Molecular Weight:446.546
Hs Code.:

Synonyms:(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

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Chemical Property of (1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

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Technology Process of (1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

There total 3 articles about (1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 33375-06-3
(1R)-1-phenylethyl isocyanate

: 120034-52-8
(+/-)-threo-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-1-isoquinolinemethanol

: 120034-53-9,120142-59-8,120142-60-1,120142-67-8
1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

Guidance literature:: In chloroform; for 1h; Ambient temperature;
DOI:10.1021/jo00274a044

Reference yield:

: 22190-45-0
(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone

: 120034-53-9,120142-59-8,120142-60-1,120142-67-8
1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 0.56 g / NaBH₄ / methanol; H₂O / 2 h / Ambient temperature

2: 80 percent / CHCl₃ / 1 h / Ambient temperature

With sodium tetrahydroborate; In methanol; chloroform; water;
DOI:10.1021/jo00274a044

Reference yield:

: 22190-45-0
(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(phenyl)methanone

: 120034-53-9
(1R,αS)-1,2,3,4-tetrahydro-6,7-dimethoxy-α-phenyl-2-<((R)-1-phenylethyl)carbamoyl>-1-isoquinolinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.88 g / NaBH₄ / methanol; H₂O / 2 h / Ambient temperature

2: 30 percent / CHCl₃ / 1 h / Ambient temperature

With sodium tetrahydroborate; In methanol; chloroform; water;
DOI:10.1021/jo00274a044