Technology Process of 7-Acetoxy-6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline
There total 8 articles about 7-Acetoxy-6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 25 ℃;
DOI:10.1021/jo00195a033
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 59 percent / 1) lithium diisopropylamide 2) acetic anhydride, sodium acetate / tetrahydrofuran / 1) a) 1h -78 deg C b) 3.75h -78 -> 25 deg C 2) 1h reflux
2: 91 percent / toluene / 24 h / 120 °C
3: 97 percent / 1.0N aqueous NaOH / methanol; tetrahydrofuran / 10 h / 25 °C
4: 1) 1N aqueous KOH 2) oxalyl chloride / 1) MeOH, 25 deg C 2) dry benzene, ca.3h, 25 deg C
5: 76 percent / tetrahydrofuran / 1 h / -78 °C
6: 62 percent / m-CPBA / CH2Cl2 / 25 °C
With
potassium hydroxide; sodium hydroxide; oxalyl dichloride; sodium acetate; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo00195a033
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 74 percent / 10percent aqueous H2SO4 / tetrahydrofuran / 20 h / 25 °C
2: 59 percent / 1) lithium diisopropylamide 2) acetic anhydride, sodium acetate / tetrahydrofuran / 1) a) 1h -78 deg C b) 3.75h -78 -> 25 deg C 2) 1h reflux
3: 91 percent / toluene / 24 h / 120 °C
4: 97 percent / 1.0N aqueous NaOH / methanol; tetrahydrofuran / 10 h / 25 °C
5: 1) 1N aqueous KOH 2) oxalyl chloride / 1) MeOH, 25 deg C 2) dry benzene, ca.3h, 25 deg C
6: 76 percent / tetrahydrofuran / 1 h / -78 °C
7: 62 percent / m-CPBA / CH2Cl2 / 25 °C
With
potassium hydroxide; sodium hydroxide; oxalyl dichloride; sulfuric acid; sodium acetate; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo00195a033
