Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

Base Information

Chemical Name:Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate
CAS No.:91586-29-7
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:

Synonyms:Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

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Chemical Property of Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

Chemical Property:

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Technology Process of Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

There total 4 articles about Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 922-69-0
1,1-dimethoxyethylene

: 91586-27-5
6-(4-Methoxy-benzoyl)-2-oxo-5,6,7,8-tetrahydro-2H-pyrano[3,2-c]pyridine-3-carboxylic acid methyl ester

: 91586-29-7
Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

Guidance literature:: In toluene; at 120 ℃; for 24h;
DOI:10.1021/jo00195a033

Reference yield:

: 91586-26-4
1-(4-methoxybenzoyl)piperidin-4-one

: 91586-29-7
Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / 1) lithium diisopropylamide 2) acetic anhydride, sodium acetate / tetrahydrofuran / 1) a) 1h -78 deg C b) 3.75h -78 -> 25 deg C 2) 1h reflux

2: 91 percent / toluene / 24 h / 120 °C

With sodium acetate; acetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1021/jo00195a033

Reference yield:

: 190012-08-9
1-(4-methoxybenzoyl)-4-piperidone ethylene ketal

: 91586-29-7
Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / 10percent aqueous H₂SO₄ / tetrahydrofuran / 20 h / 25 °C

2: 59 percent / 1) lithium diisopropylamide 2) acetic anhydride, sodium acetate / tetrahydrofuran / 1) a) 1h -78 deg C b) 3.75h -78 -> 25 deg C 2) 1h reflux

3: 91 percent / toluene / 24 h / 120 °C

With sulfuric acid; sodium acetate; acetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1021/jo00195a033