N-Anisoyl-4-piperidone

Base Information

• Chemical Name: N-Anisoyl-4-piperidone
• CAS No.: 91586-26-4
• Molecular Formula: C13H15 N O3
• Molecular Weight: 233.267
• Hs Code.: 2933399090
• Mol file: 91586-26-4.mol

Synonyms:N-Anisoyl-4-piperidone

Chemical Property of N-Anisoyl-4-piperidone

Chemical Property:

• PSA: 46.61000
• LogP: 1.43820

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Methoxy-benzoyl)-piperidin-4-one 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Anisoyl-4-piperidone

There total 5 articles about N-Anisoyl-4-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.2%

piperidin-4-one (41661-47-6) + 4-methoxy-benzoyl chloride (100-07-2) → 1-(4-methoxybenzoyl)piperidin-4-one (91586-26-4)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 1h;

Reference yield: 74.0%

1-(4-methoxybenzoyl)-4-piperidone ethylene ketal (190012-08-9) → 1-(4-methoxybenzoyl)piperidin-4-one (91586-26-4)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; at 25 ℃; for 20h;

DOI:10.1021/jo00195a033

Reference yield: 61.5%

4-piperidone hydrochloride (41979-39-9) + 4-methoxy-benzoyl chloride (100-07-2) → 1-(4-methoxybenzoyl)piperidin-4-one (91586-26-4)

Guidance literature:

With pyridine; at 20 ℃; for 18h;

upstream raw materials:

1-(4-methoxybenzoyl)-4-piperidone ethylene ketal

4-methoxy-benzoyl chloride

4,4-ethylenedioxy-piperidine

4-piperidone hydrochloride

Downstream raw materials:

C₁₅H₂₀N₂O₃

7-Acetoxy-6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline

6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carbonyl chloride

Refernces

• 1、 -. "NOVEL ANALGESIC THAT BINDS FILAMIN A". Page/Page column 30-31. . Retrieved 2010/12/29.