methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate

Base Information

• Chemical Name: methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate
• CAS No.: 1352077-05-4
• Molecular Formula: C₄₂H₄₇Cl₂NO₄Si
• Molecular Weight: 728.831
• Mol file: 1352077-05-4.mol

Synonyms:methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate

Chemical Property of methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate

There total 4 articles about methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methanol (67-56-1) + 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid (1352072-84-4) → methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate (1352077-05-4)

Guidance literature:

With diazomethyl-trimethyl-silane; In hexane; benzene; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm401753e

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate (1352077-05-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

2: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

3: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 0 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; ruthenium(III) trichloride hydrate; diazomethyl-trimethyl-silane; In tetrachloromethane; hexane; water; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm401753e

Reference yield:

C42H47Cl2NO2Si (1352072-98-0) → methyl 2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate (1352077-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

2: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 0 °C / Inert atmosphere

With sodium periodate; ruthenium(III) trichloride hydrate; diazomethyl-trimethyl-silane; In tetrachloromethane; hexane; water; acetonitrile; benzene;

DOI:10.1021/jm401753e

upstream raw materials:

methanol

2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

tert-butylchlorodiphenylsilane

C₄₂H₄₇Cl₂NO₂Si

Downstream raw materials:

methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-hydroxyethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

methyl 2-((3R,5R,6S)-1-((S)-2-(benzylthio)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetate