methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

Base Information

Chemical Name:methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate
CAS No.:1559022-43-3
Molecular Formula:C₂₈H₃₄Cl₂N₂O₅S
Molecular Weight:581.56
Hs Code.:

Synonyms:methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

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Chemical Property of methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

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Technology Process of methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

There total 7 articles about methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: C₂₆H₂₉Cl₂NO₆S

: 124-40-3
dimethyl amine

: 1559022-43-3
methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm401753e

Reference yield:

: 1352072-84-4
2-((3R,5R,6S)-1-((S)-2-(tert-butyldiphenylsilyloxy)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1559022-43-3
methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 - 25 °C

3: cyanomethylenetributyl-phosphorane / 2 h / 100 °C

4: iodosylbenzene; hydrogenchloride / diethyl ether / 0.5 h / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere

With hydrogenchloride; iodosylbenzene; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; diazomethyl-trimethyl-silane; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; benzene;
DOI:10.1021/jm401753e

Reference yield:

: 1352072-98-0
C₄₂H₄₇Cl₂NO₂Si

: 1559022-43-3
methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-(N,N-dimethylsulfamoyl)ethyl)-3-methyl-2-oxopiperidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

2: diazomethyl-trimethyl-silane / benzene; hexane / 1 h / 0 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 - 25 °C

4: cyanomethylenetributyl-phosphorane / 2 h / 100 °C

5: iodosylbenzene; hydrogenchloride / diethyl ether / 0.5 h / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere

With hydrogenchloride; sodium periodate; ruthenium(III) trichloride hydrate; iodosylbenzene; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; diazomethyl-trimethyl-silane; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; acetonitrile; benzene;
DOI:10.1021/jm401753e