2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone

Base Information

• Chemical Name: 2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone
• CAS No.: 130235-11-9
• Molecular Formula: C₁₂H₁₄Cl₂O₄S₂
• Molecular Weight: 357.279
• Mol file: 130235-11-9.mol

Synonyms:2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone

Chemical Property of 2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone

There total 2 articles about 2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-(3-hydroxypropylthio)-2',4'-dichloroacetophenone (130235-08-4) + methanesulfonyl chloride (124-63-0) → 2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone (130235-11-9)

Guidance literature:

With triethylamine; In dichloromethane; at -15 ℃; for 0.0833333h;

DOI:10.1248/cpb.38.1258

Reference yield:

2,2',4'-trichloroacetophenone (4252-78-2) → 2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone (130235-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 0 deg C, 15 min, 2) 0 deg C, 20 min

2: 71 percent / Et₃N / CH₂Cl₂ / 0.08 h / -15 °C

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1248/cpb.38.1258

Reference yield:

2-<3-(methanesulfonyloxy)propylthio>-2',4'-dichloroacetophenone (130235-11-9) → 2,4-dichlorophenyl 2-thiolanyl ketone (130235-14-2) + 2-(2,4-Dichloro-phenyl)-6,7-dihydro-5H-[1,4]oxathiepine (130235-17-5)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at 50 - 55 ℃; for 0.5h; Yield given. Yields of byproduct given;

DOI:10.1248/cpb.38.1258

upstream raw materials:

2-(3-hydroxypropylthio)-2',4'-dichloroacetophenone

methanesulfonyl chloride

2,2',4'-trichloroacetophenone

Downstream raw materials:

2,4-dichlorophenyl 2-thiolanyl ketone

2-(2,4-Dichloro-phenyl)-6,7-dihydro-5H-[1,4]oxathiepine

2,4-dichlorophenyl 2-thiolen-2-yl ketone

2,4-dichlorophenyl 2-thiolanyl ketone S-oxide