1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester
• CAS No.: 1460286-38-7
• Molecular Formula: C₂₁H₂₆N₂O₅
• Molecular Weight: 386.448
• Mol file: 1460286-38-7.mol

Synonyms:1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

Chemical Property of 1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

There total 1 articles about 1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-(4-(tert-butyl)phenyl)ethanone (30095-47-7) + diethyl 1H-pyrazole-3,5-dicarboxylate (37687-24-4) → 1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (1460286-38-7)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

Reference yield:

1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (1460286-38-7) → 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester (1460286-39-8)

Guidance literature:

With ammonium acetate; acetic acid; at 110 ℃; for 44h;

Reference yield:

1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (1460286-38-7) → 6-(4-tert-butyl-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one (1460285-43-1)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate; acetic acid / 44 h / 110 °C

2: sodium hydroxide; water / 1,2-dimethoxyethane / 48 h / 100 °C

3: copper; quinoline / 20 h / 190 °C

With quinoline; ammonium acetate; water; copper; acetic acid; sodium hydroxide; In 1,2-dimethoxyethane;

upstream raw materials:

2-bromo-1-(4-(tert-butyl)phenyl)ethanone

diethyl 1H-pyrazole-3,5-dicarboxylate

Downstream raw materials:

6-(4-tert-butyl-phenyl)-2-fluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid

6-(4-tert-butyl-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one