6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester
• CAS No.: 1460286-39-8
• Molecular Formula: C₁₉H₂₁N₃O₃
• Molecular Weight: 339.394
• Mol file: 1460286-39-8.mol

Synonyms:6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

Chemical Property of 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

There total 3 articles about 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester (1460286-38-7) → 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester (1460286-39-8)

Guidance literature:

With ammonium acetate; acetic acid; at 110 ℃; for 44h;

Reference yield:

diethyl 1H-pyrazole-3,5-dicarboxylate (37687-24-4) → 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester (1460286-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 °C

2: ammonium acetate; acetic acid / 44 h / 110 °C

With ammonium acetate; potassium carbonate; acetic acid; In acetone;

Reference yield:

2-bromo-1-(4-(tert-butyl)phenyl)ethanone (30095-47-7) → 6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester (1460286-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 °C

2: ammonium acetate; acetic acid / 44 h / 110 °C

With ammonium acetate; potassium carbonate; acetic acid; In acetone;

upstream raw materials:

diethyl 1H-pyrazole-3,5-dicarboxylate

2-bromo-1-(4-(tert-butyl)phenyl)ethanone

1-[2-(4-tert-butyl-phenyl)-2-oxo-ethyl]-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

Downstream raw materials:

6-(4-tert-butyl-phenyl)-2-fluoromethyl-5H-pyrazolo[1,5-a]pyrazin-4-one

6-(4-tert-butyl-phenyl)-4-oxo-4,5-dihydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid

6-(4-tert-butyl-phenyl)-5H-pyrazolo[1,5-a]pyrazin-4-one

6-(4-tert-butyl-phenyl)-2-hydroxymethyl-5H-pyrazolo[1,5-a]pyrazin-4-one