2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

Base Information

Chemical Name:2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine
CAS No.:1365992-72-8
Molecular Formula:C₁₂H₅BrCl₂N₂S
Molecular Weight:360.061
Hs Code.:

Synonyms:2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

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Chemical Property of 2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

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Technology Process of 2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

There total 4 articles about 2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1365992-71-7
2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

: 1365992-72-8
2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

Guidance literature:: 2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride; With pyridine; thiourea; In isopropyl alcohol; for 3h; Inert atmosphere; Reflux;

With triethylamine; In isopropyl alcohol; for 1.5h; Reflux;

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 1365992-72-8
2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 4.67 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

3.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

4.1: thiourea; pyridine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

4.2: 1.5 h / Reflux

With pyridine; thionyl chloride; caesium carbonate; thiourea; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; isopropyl alcohol;

Reference yield:

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 1365992-72-8
2-(2-bromo-6-chlorophenyl)-4-chlorothiazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

3.1: thiourea; pyridine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Reflux

With pyridine; thionyl chloride; caesium carbonate; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; isopropyl alcohol;