2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile

Base Information

Chemical Name:2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile
CAS No.:1365992-74-0
Molecular Formula:C₁₃H₅BrClN₃S
Molecular Weight:350.626
Hs Code.:

Synonyms:2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile

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Chemical Property of 2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile

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Technology Process of 2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile

There total 10 articles about 2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1365992-73-9
3-chloro-2-(4-chlorothiazolo[5,4-c]pyridine-2-yl)-benzonitrile

: 1365992-74-0
2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile

Guidance literature:: With trimethylsilyl bromide; In propiononitrile; at 20 - 85 ℃; Inert atmosphere;

Reference yield:

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 1365992-74-0
2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

3.1: thiourea; pyridine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Reflux

4.1: 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C

5.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere

With pyridine; thionyl chloride; trimethylsilyl bromide; caesium carbonate; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; isopropyl alcohol; propiononitrile;

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 1365992-74-0
2-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 4.67 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

3.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

4.1: thiourea; pyridine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

4.2: 1.5 h / Reflux

5.1: 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C

6.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere

With pyridine; thionyl chloride; trimethylsilyl bromide; caesium carbonate; thiourea; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; n-heptane; ethylbenzene; isopropyl alcohol; propiononitrile;