2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

Base Information

Chemical Name:2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride
CAS No.:1365992-71-7
Molecular Formula:C₁₂H₅BrCl₃FN₂
Molecular Weight:382.447
Hs Code.:

Synonyms:2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

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Chemical Property of 2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

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Technology Process of 2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

There total 3 articles about 2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1365992-70-6
2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzamide

: 1365992-71-7
2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

Guidance literature:: With thionyl chloride; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 1365992-71-7
2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 4.67 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

3.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

With thionyl chloride; caesium carbonate; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene;

Reference yield:

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 1365992-71-7
2-bromo-6-chloro-N-(2-chloro-3-fluoropyridin-4-yl)-benzimidoyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

2: thionyl chloride / 18 h / 100 °C / Inert atmosphere

With thionyl chloride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane;