5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
• CAS No.: 1445895-03-3
• Molecular Formula: C₃₀H₄₀ClN₅O₃S
• Molecular Weight: 586.198

Synonyms:5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Chemical Property of 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

There total 10 articles about 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine hydrochloride (1380575-43-8) + ethyl iodide (75-03-6) → 5-chloro-N2-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1445895-03-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 50 ℃;

DOI:10.1021/jm400402q

Reference yield:

1-amino-2-(isopropylsulphonyl)benzene (76697-50-2) → 5-chloro-N2-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1445895-03-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; dimethyl sulfoxide / 0 °C

1.2: 0 - 20 °C

2.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 50 °C

With palladium diacetate; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm400402q

Reference yield:

1-chloro-5-fluoro-2-methyl-4-nitrobenzene (112108-73-3) → 5-chloro-N2-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1445895-03-3)

Guidance literature:

Multi-step reaction with 7 steps

1: caesium carbonate / 60 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

3: acetic acid; trifluoroacetic acid; platinum(IV) oxide; hydrogen / 36 h / 760.05 Torr

4: triethylamine / dichloromethane / 0.5 h / 20 °C

5: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

6: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / ethanol / 50 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; platinum(IV) oxide; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; palladium diacetate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2: |Suzuki Coupling / 5: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm400402q

upstream raw materials:

5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine hydrochloride

ethyl iodide

1-chloro-5-fluoro-2-methyl-4-nitrobenzene

1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1445895-03-3 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send