2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

Base Information

Chemical Name:2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde
CAS No.:1365543-37-8
Molecular Formula:C₂₁H₂₃N₃O₄
Molecular Weight:381.431
Hs Code.:

Synonyms:2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

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Chemical Property of 2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

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Technology Process of 2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

There total 7 articles about 2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1365543-37-8
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 4 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 12 h / 20 °C

3: sodium metabisulfite / ethanol; water / 2 h / Reflux

4: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 - 0 °C

With sodium metabisulfite; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 1365543-37-8
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3: 5%-palladium/activated carbon; hydrogen / methanol / 40 h / 20 °C

4: sodium metabisulfite / ethanol; water / 2 h / Reflux

5: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 - 0 °C

With oxalyl dichloride; sodium metabisulfite; 5%-palladium/activated carbon; hydrogen; diisobutylaluminium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 1365543-37-8
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 12 h / 20 °C

2: sodium metabisulfite / ethanol; water / 2 h / Reflux

3: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 - 0 °C

With sodium metabisulfite; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2012.01.042