3-acetyl-1-benzyl-2-hydroxy-6-methylpyridin-4(1H)-one

Base Information

• Chemical Name: 3-acetyl-1-benzyl-2-hydroxy-6-methylpyridin-4(1H)-one
• CAS No.: 26162-40-3
• Molecular Formula: C15H15 N O3
• Molecular Weight: 257.2845
• Mol file: 26162-40-3.mol

Synonyms:2(1H)-Pyridone,3-acetyl-1-benzyl-4-hydroxy-6-methyl- (8CI);3-Acetyl-1-benzyl-4-hydroxy-6-methyl-2(1H)-pyridinone; NSC 363845

Chemical Property of 3-acetyl-1-benzyl-2-hydroxy-6-methylpyridin-4(1H)-one

Chemical Property:

• Vapor Pressure: 4.39E-08mmHg at 25°C
• Boiling Point: 427.9°C at 760 mmHg
• Flash Point: 212.6°C
• Density: 1.279g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-acetyl-1-benzyl-2-hydroxy-6-methylpyridin-4(1H)-one

There total 3 articles about 3-acetyl-1-benzyl-2-hydroxy-6-methylpyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1,3-diacetyl acetone (626-53-9) + benzyl isothiocyanate (3173-56-6) → 2,6-dimethyl-4-oxo-4H-pyran-3,5-dicarboxylic acid bis-benzylamide (1251617-86-3) + 3-acetyl-1-benzyl-4-hydroxy-6-methyl-1H-pyridin-2-one (26162-40-3)

Guidance literature:

With zinc(II) acetylacetonate; In 1,2-dichloro-ethane; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.tet.2010.07.070

Reference yield: 20.0%

ethyl 3-(benzylamino)crotonate (1020-67-3) + 3-mercaptopropionic acid (107-96-0) → 3-acetyl-1-benzyl-4-hydroxy-6-methyl-1H-pyridin-2-one (26162-40-3) + 1,6-dibenzyl-4-hydroxy-7-methyl-1H,6H-1,6-naphthyridine-2,5-dione (82616-41-9)

Guidance literature:

at 160 ℃; for 30h;

Reference yield:

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + N-benzyl-3-benzamidocrotonamide (108380-11-6) → 3-acetyl-1-benzyl-4-hydroxy-6-methyl-1H-pyridin-2-one (26162-40-3)

Guidance literature:

With hydrogenchloride; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, RT; 2.) CH₃OH, 1.5 h, reflux.;

upstream raw materials:

4-methyleneoxetan-2-one

N-benzyl-3-benzamidocrotonamide

ethyl 3-(benzylamino)crotonate

3-mercaptopropionic acid

Downstream raw materials:

3-acetyl-1-benzyl-4-methoxy-6-methyl-2-pyridone

1-benzyl-3-(1-hydroxyethyl)-4-methoxy-6-methyl-2-pyridone

2-benzyl-4-(1-hydroxyethyl)-1-methyl-2-azabicyclo<2.2.0>hexane-3,5-dione

2-benzyl-4-(1-hydroxyethyl)-5-methoxy-1-methyl-2-azabicyclo<2.2.0>hex-5-en-3-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 26162-40-3 3-acetyl-1-benzyl-2-hydroxy-6-methylpyridin-4(1H)-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send