(E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate

Base Information Edit

Chemical Name:(E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate
CAS No.:1312099-51-6
Molecular Formula:C₁₇H₁₅NO₂S
Molecular Weight:297.378
Hs Code.:
Mol file:1312099-51-6.mol

Synonyms:(E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate

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Chemical Property of (E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate Edit

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Technology Process of (E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate

There total 2 articles about (E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1312099-47-0
4-(4-bromothiophen-3-yl)-3-methylbenzonitrile

: 140-88-5,9003-32-1
ethyl acrylate

: 1312099-51-6
(E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate

Guidance literature:: palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 150 ℃; Inert atmosphere;

Reference yield:

: 848953-05-9
3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1312099-51-6
(E)-ethyl 3-(4-(4-cyano-2-methylphenyl)thiophen-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 80 °C / Inert atmosphere

2: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 150 °C / Inert atmosphere

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; triphenylphosphine; In ethanol; water; N,N-dimethyl-formamide; toluene;