Iohexol

Base Information

Chemical Name:Iohexol
CAS No.:66108-95-0
Molecular Formula:C19H26I3N3O9
Molecular Weight:821.144
Hs Code.:2924296000
European Community (EC) Number:266-164-2
UNII:4419T9MX03
DSSTox Substance ID:DTXSID6023157
Nikkaji Number:J18.922G
Wikipedia:Iohexol
Wikidata:Q410683
NCI Thesaurus Code:C65939
RXCUI:5956
Metabolomics Workbench ID:43519
ChEMBL ID:CHEMBL1200455

Synonyms:Compound 545;Exypaque;Iohexol;Iohexol 350;Nycodenz;Omnipaque

Suppliers and Price of Iohexol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Iohexol
100mg
$ 355.00

TRC
Iohexol
1g
$ 55.00

TCI Chemical
Iohexol (mixture of isomers) >98.0%(HPLC)(N)
5g
$ 43.00

TCI Chemical
Iohexol (mixture of isomers) >98.0%(HPLC)(N)
25g
$ 141.00

Sigma-Aldrich
Iohexol European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Iohexol for peak identification European Pharmacopoeia (EP) Reference Standard
y0000672
$ 190.00

Sigma-Aldrich
Iohexol European Pharmacopoeia (EP) Reference Standard
i0320800
$ 190.00

Sigma-Aldrich
Iohexol analytical standard
50mg
$ 88.70

Sigma-Aldrich
Iohexol Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 129.00

Sigma-Aldrich
Histodenz? nonionic density gradient medium
100g
$ 413.00

Total 169 raw suppliers

Chemical Property of Iohexol

Chemical Property:

Appearance/Colour:White solid
Melting Point:254-256 °C
Boiling Point:891.5 °C at 760 mmHg
PKA:11.35±0.46(Predicted)
Flash Point:493 °C
PSA：199.89000
Density:2.2 g/cm³
LogP:-0.84570
Storage Temp.:−20°C
Solubility.:Very soluble in water, freely soluble in methanol, practically insoluble in methylene chloride.
XLogP3:-3
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:12
Exact Mass:820.8803
Heavy Atom Count:34
Complexity:653

Purity/Quality:

≥99.0% ^*data from raw suppliers

Iohexol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N(CC(CO)O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I
Recent ClinicalTrials:Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance
Recent EU Clinical Trials:Proposta di studio per valutare l’efficacia di Obinutuzumab, un anticorpo anti-CD20, in pazienti con nefropatia membranosa intolleranti, resistenti o dipendenti alla terapia con Rituximab (studio ORION)
Recent NIPH Clinical Trials:Evaluation of the tumor blood flow by computed tomography(CT)perfusion imaging and an effect of chemotherapy or radiotherapy for esophageal cancer
Uses It is the raw material for the production of water-soluble, non-ionic X-CT contrast agent in pharmaceutical factory. The trade name of this contrast agent is Omnipaque. This contrast agent is usually injected into the vein before CT angiography to be used for angiography, urinary system, spinal cord and joint, lymphatic system angiography, with advantages of low contrast density, low toxicity and good tolerance type. Iohexol is also currently one of the best contrast agents. The developed countries have completely used it to replace ionography agent. It is also a diagnostic drug. It can be used as non-ionic X-CT contrast agent. Imaging agent antibacterial Imaging agent.

Technology Process of Iohexol

There total 14 articles about Iohexol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 31127-80-7
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 66108-95-0
iohexol

: 92339-11-2
iodixanol

Guidance literature:: With hydrogenchloride; boric acid; potassium hydroxide; In water; pH=10 - 11; Product distribution / selectivity; Industry scale;