4-methyl-2,3-diphenylquinoline

Base Information

• Chemical Name: 4-methyl-2,3-diphenylquinoline
• CAS No.: 6829-12-5
• Molecular Formula: C₂₂H₁₇N
• Molecular Weight: 295.384
• Mol file: 6829-12-5.mol

Synonyms:4-methyl-2,3-diphenylquinoline

Chemical Property of 4-methyl-2,3-diphenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-2,3-diphenylquinoline

There total 12 articles about 4-methyl-2,3-diphenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenyl benzyl ketone (451-40-1) + 2-aminoacetophenone (551-93-9) → 4-methyl-2,3-diphenylquinoline (6829-12-5)

Guidance literature:

With sulfuric acid; In acetic acid; Inert atmosphere; Reflux;

DOI:10.1016/j.jorganchem.2009.06.003

Reference yield: 70.0%

3-methylbenzo[c]isoxazole (4127-53-1) + diphenyl acetylene (501-65-5) → 4-methyl-2,3-diphenylquinoline (6829-12-5)

Guidance literature:

With 6,6'-dimethyl-2,2'-bipyridine; nickel(II) tetrafluoroborate hexahydrate; diethoxymethylane; In N,N-dimethyl acetamide; at 40 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acscatal.1c02055

Reference yield: 65.0%

1-(2-aminophenyl)ethanol (941706-81-6) + diphenyl acetylene (501-65-5) → 4-methyl-2,3-diphenylquinoline (6829-12-5)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00817

upstream raw materials:

phenyl benzyl ketone

2-aminoacetophenone

diphenyl acetylene

1-(2-aminophenyl)ethanol

Downstream raw materials:

Ir(2-phenylpyridine)2(4-methyl-2,3-diphenylqionoline)

Ir(2-phenylquinoline)2(4-methyl-2,3-diphenylquinoline)

(iridium)(μ-Cl)2(iridium)(4-methyl-2,3-diphenylquinolinate)2

Refernces

• 1、 Talbot, Fabien J. T.,Zhang, Shibo,Satpathi, Bishnupada,Howell, Gareth P.,Perry, Gregory J. P.,Crisenza, Giacomo E. M.,Procter, David J.. "Modular Synthesis of Stereodefined Benzocyclobutene Derivatives via Sequential Cu- And Pd-Catalysis". . p. 14448 - 14455. Retrieved 2021/12/01.
• 2、 Saunthwal, Rakesh K.,Patel, Monika,Verma, Akhilesh K.. "Metal- and Protection-Free [4 + 2] Cycloadditions of Alkynes with Azadienes: Assembly of Functionalized Quinolines". . p. 2200 - 2203. Retrieved 2016/06/01.