(S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate

Base Information

Chemical Name:(S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate
CAS No.:1124258-87-2
Molecular Formula:C₂₆H₃₇NO₅Si
Molecular Weight:471.669
Hs Code.:

Synonyms:(S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate

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Chemical Property of (S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate

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Technology Process of (S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate

There total 1 articles about (S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 98-98-6
2-Picolinic acid

: 953436-77-6
(S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-ol

: 1124258-87-2
(S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo802426g

Reference yield: 81.0%

: 1124258-87-2
(S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate

: 100-58-3
phenylmagnesium bromide

: 1124258-91-8
(R,E)-tert-butyl((5-((4-methoxybenzyl)oxy)-4-methyl-4-phenylpent-2-en-1-yl)oxy)dimethylsilane

Guidance literature:: phenylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -60 - 0 ℃;

(S,E)-1-[(tert-butyldimethylsilyl)oxy]-5-(4-methoxybenzyloxy)-4-methylpent-3-en-2-yl pyridine-2-carboxylate; In tetrahydrofuran; at -60 ℃; for 1h; optical yield given as %ee;
DOI:10.1021/jo802426g