Levofloxacin Tetrafluoro Impurity 1

Base Information Edit

Chemical Name:Levofloxacin Tetrafluoro Impurity 1
CAS No.:110548-02-2
Molecular Formula:C₁₅H₁₅F₄NO₄
Molecular Weight:349.282
Hs Code.:
Mol file:110548-02-2.mol

Synonyms:(+)-ethyl 2-<<<(S)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

Suppliers and Price of Levofloxacin Tetrafluoro Impurity 1

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,3,4,5-Tetrafluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster
5g
$ 3850.00

TRC
2,3,4,5-Tetrafluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster
1g
$ 880.00

TRC
2,3,4,5-Tetrafluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster
500mg
$ 495.00

TRC
2,3,4,5-Tetrafluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster
100mg
$ 120.00

Total 6 raw suppliers

Chemical Property of Levofloxacin Tetrafluoro Impurity 1 Edit

Chemical Property:

Boiling Point:463.5±45.0 °C(Predicted)
PKA:14.47±0.10(Predicted)
Density:1.359±0.06 g/cm3(Predicted)

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,3,4,5-Tetrafluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2,3,4,5-Tetrafluoro-α-[[[(1S)-2-hydroxy-1-methylethyl]amino]methylene]-β-oxo-benzenepropanoic Acid Ethyl Ester is used in the synthesis of the drug Levofloxacin (L360000), which is a S-(-) form of Ofloxacin (O245750), an antibiotic used against gram-negative organisms.

Technology Process of Levofloxacin Tetrafluoro Impurity 1

There total 3 articles about Levofloxacin Tetrafluoro Impurity 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2749-11-3
(S)-Alaninol

: 103995-33-1
3-(2,3,4,5-tetrafluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester

: 110548-02-2
(+)-ethyl 2-<<<(S)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

Guidance literature:: In diethyl ether; ethanol; at 0 ℃;
DOI:10.1016/j.bmcl.2007.11.110

Reference yield:

: 2749-11-3
(S)-Alaninol

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 122-51-0
orthoformic acid triethyl ester

: 110548-02-2
(+)-ethyl 2-<<<(S)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

Guidance literature:: ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate; orthoformic acid triethyl ester; With acetic anhydride; for 3h; Heating / reflux;

(S)-Alaninol; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 110548-02-2
(+)-ethyl 2-<<<(S)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 2 h / 110 °C

2: CH₂Cl₂ / 0.5 h / Ambient temperature

In dichloromethane; acetic anhydride;
DOI:10.1021/jm00395a017