cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

Base Information

• Chemical Name: cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane
• CAS No.: 28097-12-3
• Molecular Formula: C₆H₁₂ClO₄P
• Molecular Weight: 214.586
• Mol file: 28097-12-3.mol

Synonyms:

Chemical Property of cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

There total 18 articles about cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + cis-2-chloro-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (21071-81-8) → cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (28097-12-3)

Guidance literature:

With potassium tert-butylate; for 0.166667h;

DOI:10.1021/ja00344a035

Reference yield:

methanol (67-56-1) + 5-Chloromethyl-2-fluoro-5-methyl-[1,3,2]dioxaphosphinane 2-oxide (343863-92-3) → cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (28097-12-3) + trans-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-27-3)

Guidance literature:

With cesium fluoride; In tetrahydrofuran;

DOI:10.1021/ja00316a041

Reference yield:

methanol (67-56-1) + trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide (28097-07-6) → cis-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (28097-12-3) + trans-2-methoxy-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane (36912-27-3)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; Product distribution; var. time, reagent:triethylamine, further alcohols and phenols; kinetic and thermodynamic product-ratio;

DOI:10.1021/ja00316a041

upstream raw materials:

methanol

trans-2-(p-Nitrophenyl)-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinan

trans-2-chloro-5-methyl-1,3,2-dioxaphosphorinane-r-5-methyl chloride 2-oxide

cis-2-chloro-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinane

Downstream raw materials:

2-Methyl-5-(chloromethyl)-5-methyl-2-oxo-1,3,2-dioxaphosphorinan